{ "reportId": "EOS-LIBORAY-RAPID-20261006-R01", "version": "R01", "date": "2026-10-06", "status": "preliminary_rapid_appraisal", "professionalReview": "pending", "productHumanTrial": "not_supplied", "openEvidence": { "status": "not_used_access_blocked", "detail": "403 after one retry; no account query completed" }, "title": { "zh": "利葆瑞运动耐力方向｜快速证据评估", "en": "Libaorui endurance positioning | Rapid evidence appraisal" }, "scope": { "zh": "根据5份既有资料，定向核对牛磺酸、镁及谷胱甘肽相关人体研究。7篇研究是本轮重点核对样本，不是系统检索的全部结果；其他营养素未作完整运动证据评价。", "en": "Five project inputs and seven selected human studies inform this focused appraisal of taurine, magnesium and glutathione. This is not an exhaustive review; other nutrients were not fully appraised for exercise outcomes." }, "methods": { "zh": "检索日：2026年10月6日。通过网络检索定位 PubMed 原始摘要与可用期刊全文，再追溯题录；摘要与全文层次逐项标明。未执行双人独立筛选、正式偏倚分级、GRADE或Meta合并。专业复核待安排。", "en": "Retrieved 6 October 2026 using web-assisted discovery of original PubMed abstracts and available journal full text. Access depth is recorded by study. No duplicate independent screening, formal risk-of-bias/GRADE assessment or meta-analysis was performed. Professional review is pending." }, "inputs": [ { "name": "利葆瑞成分.xlsx", "use": { "zh": "单片与每日4片含量；本次剂量匹配基线。", "en": "Per-tablet and four-tablet daily amounts; the dose-matching baseline." } }, { "name": "利葆瑞®长期营养支持方案.pdf", "use": { "zh": "33页，七个健康方向；属于既有方案，不是成品临床结果。", "en": "33-page dossier covering seven health areas; not finished-product clinical results." } }, { "name": "利葆瑞初稿.docx", "use": { "zh": "既有成分机制和参考文献线索。", "en": "Ingredient rationale and bibliographic leads." } }, { "name": "利葆瑞-海报用权威依据文字.docx", "use": { "zh": "既有临床营养说明；通用营养指南不等于本产品验证。", "en": "Existing nutrition rationale; general guidance does not validate this product." } }, { "name": "利葆瑞骨科肿瘤海报-修改意见.docx", "use": { "zh": "旧场景宣传稿；不能据此认定本产品临床效益。", "en": "Prior promotional draft; does not establish clinical product benefits." } } ], "formula": [ { "ingredient": { "zh": "牛磺酸", "en": "Taurine" }, "daily": "300 mg" }, { "ingredient": { "zh": "膳食纤维（抗性糊精＋菊粉）", "en": "Fibre (resistant dextrin + inulin)" }, "daily": "1 g" }, { "ingredient": { "zh": "元素镁（氧化镁来源）", "en": "Elemental magnesium (from oxide)" }, "daily": "150 mg" }, { "ingredient": { "zh": "元素锌", "en": "Elemental zinc" }, "daily": "10.4 mg" }, { "ingredient": { "zh": "硒", "en": "Selenium" }, "daily": "24 µg" }, { "ingredient": { "zh": "维生素C", "en": "Vitamin C" }, "daily": "60 mg" }, { "ingredient": { "zh": "维生素E（α-TE）", "en": "Vitamin E (α-TE)" }, "daily": "10 mg" }, { "ingredient": { "zh": "维生素D3", "en": "Vitamin D3" }, "daily": "4 µg" }, { "ingredient": { "zh": "维生素B1", "en": "Vitamin B1" }, "daily": "1.2 mg" }, { "ingredient": { "zh": "维生素B2", "en": "Vitamin B2" }, "daily": "1.2 mg" }, { "ingredient": { "zh": "烟酰胺", "en": "Niacinamide" }, "daily": "6 mg" }, { "ingredient": { "zh": "D-泛酸钙", "en": "Calcium D-pantothenate" }, "daily": "2 mg" }, { "ingredient": { "zh": "生物素", "en": "Biotin" }, "daily": "10 µg" } ], "formulaNote": { "zh": "上述数值来自提交的成分表，不是已核准标签或批次检测。表内未列谷胱甘肽含量；现有方案提及谷胱甘肽不能补上这一缺失。每日4片仅为资料记录，不是本报告给出的服用建议。", "en": "Amounts come from the submitted sheet, not a verified label or batch assay. Glutathione content is absent from that sheet; its mention in the dossier does not resolve the gap. Four tablets is a recorded input, not a dosing recommendation." }, "queries": [ "taurine 1 g 3 km running time trial Balshaw 2013 PubMed", "taurine 1.66 g cycling endurance Rutherford Spriet Stellingwerff 2010 PubMed", "site.pubmed.ncbi.nlm.nih.gov/25008857 Effect oral magnesium supplementation physical performance healthy elderly women 300 124", "site.pubmed.ncbi.nlm.nih.gov/40077784 magnesium supplementation endurance recreationally active" ], "studies": [ { "id": "T1", "citation": "Balshaw et al., 2013", "title": "The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners", "url": "https://pubmed.ncbi.nlm.nih.gov/22855206/", "doi": "10.1007/s00726-012-1372-1", "access": { "zh": "原始摘要", "en": "Original abstract" }, "ingredient": { "zh": "牛磺酸", "en": "Taurine" }, "direction": { "zh": "特定场景阳性", "en": "Positive in this setting" }, "population": { "zh": "8名受训男性中跑运动员；随机双盲交叉。", "en": "8 trained male runners; randomised double-blind crossover." }, "dose": { "zh": "单次1,000 mg，跑前2小时。", "en": "1,000 mg once, 2 h pre-run." }, "result": { "zh": "3 km计时646.6±52.8 vs 658.5±58.2秒；P=0.013。", "en": "3-km time: 646.6±52.8 vs 658.5±58.2 s; P=0.013." }, "match": { "zh": "小样本；与300 mg/日及复方不匹配，不能直接外推产品效应。", "en": "Small sample; dose and formulation differ from 300 mg/day. No direct product-effect inference." } }, { "id": "T2", "citation": "Ward et al., 2016", "title": "The effect of acute taurine ingestion on 4-km time trial performance in trained cyclists", "url": "https://pubmed.ncbi.nlm.nih.gov/27380030/", "doi": "10.1007/s00726-016-2282-4", "access": { "zh": "原始摘要及开放全文资料", "en": "Original abstract and open full-text material" }, "ingredient": { "zh": "牛磺酸", "en": "Taurine" }, "direction": { "zh": "未见计时收益", "en": "No time-trial benefit" }, "population": { "zh": "11名受训男性骑行者；随机双盲交叉。", "en": "11 trained male cyclists; randomised double-blind crossover." }, "dose": { "zh": "单次1,000 mg，骑行前2小时。", "en": "1,000 mg once, 2 h pre-cycling." }, "result": { "zh": "4 km计时390±27 vs 388±21秒；P=0.731。", "en": "4-km time: 390±27 vs 388±21 s; P=0.731." }, "match": { "zh": "同剂量在不同运动结局下未见收益；不能概括为所有耐力运动有效。", "en": "No benefit for this outcome at the same dose; a universal endurance claim is unsupported." } }, { "id": "T3", "citation": "Rutherford et al., 2010", "title": "The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists", "url": "https://pubmed.ncbi.nlm.nih.gov/20739720/", "doi": "10.1123/ijsnem.20.4.322", "access": { "zh": "原始摘要", "en": "Original abstract" }, "ingredient": { "zh": "牛磺酸", "en": "Taurine" }, "direction": { "zh": "表现未改善", "en": "Performance unchanged" }, "population": { "zh": "11名耐力训练男性骑行者；随机交叉、盲法。", "en": "11 endurance-trained male cyclists; randomised blinded crossover." }, "dose": { "zh": "单次1.66 g，运动前1小时。", "en": "1.66 g once, 1 h pre-exercise." }, "result": { "zh": "90分钟骑行后计时无差异；脂肪氧化增加不等于成绩提高。", "en": "No post-90-min time-trial difference; greater fat oxidation did not mean better performance." }, "match": { "zh": "剂量、运动和指标与产品有差异；代谢指标不能替代耐力终点。", "en": "Dose, exercise and measures differ; metabolic markers cannot substitute for endurance outcomes." } }, { "id": "M1", "citation": "Finstad et al., 2001", "title": "The effects of magnesium supplementation on exercise performance", "url": "https://pubmed.ncbi.nlm.nih.gov/11252079/", "doi": "10.1097/00005768-200103000-00024", "access": { "zh": "原始摘要；剂量口径待全文复核", "en": "Original abstract; dose convention needs full-text review" }, "ingredient": { "zh": "镁", "en": "Magnesium" }, "direction": { "zh": "表现与恢复未改善", "en": "Performance/recovery unchanged" }, "population": { "zh": "32名活跃年轻女性；双盲安慰剂交叉。", "en": "32 active young women; double-blind placebo crossover." }, "dose": { "zh": "摘要记氧化镁212 mg/日，4周；不自行换算元素镁。", "en": "Abstract: Mg oxide 212 mg/day for 4 weeks; elemental equivalence unresolved." }, "result": { "zh": "离子镁升高，运动表现与恢复指标未显著改善。", "en": "Ionised Mg increased; performance and recovery did not significantly improve." }, "match": { "zh": "生化改变不等于功能效益；暂不与产品元素镁150 mg作比例比较。", "en": "Biochemical change is not functional benefit; no ratio to the product's 150 mg elemental Mg is assigned." } }, { "id": "M2", "citation": "Veronese et al., 2014", "title": "Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial", "url": "https://pubmed.ncbi.nlm.nih.gov/25008857/", "doi": "10.3945/ajcn.113.080168", "access": { "zh": "原始摘要及期刊全文资料", "en": "Original abstract and journal full-text material" }, "ingredient": { "zh": "镁", "en": "Magnesium" }, "direction": { "zh": "身体功能条件性阳性", "en": "Conditional physical-function benefit" }, "population": { "zh": "139名老年女性随机，124名分析；无安慰剂，研究者盲法。", "en": "139 older women randomised, 124 analysed; no placebo, researchers blinded." }, "dose": { "zh": "镁300 mg/日，氧化镁制剂，12周。", "en": "Mg 300 mg/day as oxide for 12 weeks." }, "result": { "zh": "SPPB组间变化差0.41分，P=0.03；低摄入者信号更明显。", "en": "SPPB change difference: 0.41 points, P=0.03; signal stronger with lower intake." }, "match": { "zh": "是老年身体功能而非耐力赛成绩；不能外推年轻受训人群或本配方。", "en": "Older-adult function, not endurance racing; not directly transferable to young athletes or this formulation." } }, { "id": "M3", "citation": "Bomar et al., 2025", "title": "Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial", "url": "https://pubmed.ncbi.nlm.nih.gov/40077784/", "doi": "10.3390/nu17050915", "access": { "zh": "原始摘要及开放全文资料", "en": "Original abstract and open full-text material" }, "ingredient": { "zh": "镁", "en": "Magnesium" }, "direction": { "zh": "计时无收益／部分不利", "en": "No TT benefit; some adverse signals" }, "population": { "zh": "15名规律运动成人，基线镁正常；随机双盲交叉。", "en": "15 regular exercisers with normal baseline Mg; randomised double-blind crossover." }, "dose": { "zh": "论文记MgCl₂ 300 mg、每日两次、9天；元素镁口径待核。", "en": "Reported MgCl₂ 300 mg twice daily for 9 days; elemental convention unresolved." }, "result": { "zh": "10 km计时无差异（P=0.89）；VO₂max及冲刺均功率降低。", "en": "10-km TT unchanged (P=0.89); VO₂max and mean sprint power decreased." }, "match": { "zh": "说明需分人群评价；剂量和制剂不同，不能据此认定本产品有害。", "en": "Supports population-specific appraisal; different dose/form prevents a product-harm conclusion." } }, { "id": "G1", "citation": "Aoi et al., 2015", "title": "Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism", "url": "https://link.springer.com/article/10.1186/s12970-015-0067-x", "doi": "10.1186/s12970-015-0067-x", "access": { "zh": "原始全文；随机化方法未明确", "en": "Original full text; randomisation method unclear" }, "ingredient": { "zh": "谷胱甘肽", "en": "Glutathione" }, "direction": { "zh": "探索性疲劳线索", "en": "Exploratory fatigue signal" }, "population": { "zh": "8名不规律运动男性；双盲交叉。", "en": "8 men without regular exercise; double-blind crossover." }, "dose": { "zh": "1 g/日、2周；低强度骑行60分钟。", "en": "1 g/day for 2 weeks; 60-min low-intensity cycling." }, "result": { "zh": "部分主观疲劳指标降低；未测计时成绩或力竭时间。", "en": "Some subjective fatigue measures improved; no TT or time-to-exhaustion outcome." }, "match": { "zh": "产品含量缺失；线粒体机制数据来自小鼠，不能作为人体耐力或成品证明。", "en": "Product content unknown; mitochondrial findings are in mice, not proof of human endurance or product efficacy." } } ], "findings": [ { "title": { "zh": "有研究线索，不能直接给成品功效盖章。", "en": "Ingredient leads do not validate the finished product." }, "body": { "zh": "牛磺酸的跑步和骑行结果不同；当前剂量、使用时点及复方均存在外推问题。本轮未核实与当前产品同配方、同剂量的人体耐力试验。", "en": "Taurine results differ between running and cycling. Dose, timing and formulation limit extrapolation. No human endurance trial matching this product and dose was verified in this appraisal." } }, { "title": { "zh": "个体化证据首先是适用条件的核对。", "en": "Personalised evidence starts with applicability." }, "body": { "zh": "训练水平、运动类型、年龄、营养状态、剂量与结局需分别评价。已有老年身体功能结果不等于年轻运动员耐力收益；缺数据的人群保留空白。", "en": "Training, sport, age, nutrient status, dose and outcome need separate appraisal. Older-adult functional findings do not imply athletic endurance gains. Unsupported populations retain an evidence gap." } }, { "title": { "zh": "下一步先做可行性，再决定SR／Meta或产品试验。", "en": "Assess feasibility before commissioning SR/Meta or a product trial." }, "body": { "zh": "预设牛磺酸与耐力表现的PICO，完整检索后才判断是否能合并。若目标是证明当前利葆瑞成品，则需考虑产品人体研究；文献合并不能替代它。", "en": "Predefine a taurine/endurance PICO and search comprehensively before deciding on pooling. Establishing effects of the actual Libaorui formulation may require a product human study; literature synthesis cannot replace it." } } ], "missing": [ { "zh": "现行产品标签、批准或许可依据、SKU版本及批次检测。", "en": "Current label, applicable licence/category documents, SKU version and batch assays." }, { "zh": "谷胱甘肽来源、每日含量及含量测定；成分表与现配方是否一致。", "en": "Glutathione source, daily quantity and assay; reconciliation of the sheet with the current formulation." }, { "zh": "成品人体研究、训练与饮食控制、耐力结局、耐受性和利益冲突资料。", "en": "Finished-product human studies, exercise/diet controls, endurance outcomes, tolerability and conflicts." }, { "zh": "7篇研究的进一步全文复核、交叉配对统计、正式偏倚与确定性评价。", "en": "Further full-text review of all seven studies, paired crossover statistics, bias and certainty assessment." } ], "legalSources": [ { "title": { "zh": "《中华人民共和国广告法》第11、17、19条", "en": "China Advertising Law, Articles 11, 17 and 19" }, "url": "https://www.samr.gov.cn/zw/zfxxgk/fdzdgknr/fgs/art/2023/art_5474cf75173c45d6a0379730fb4e8d97.html" }, { "title": { "zh": "运动营养食品的消费提示（2026-05-27）", "en": "Sports nutrition consumer guidance (27 May 2026)" }, "url": "https://www.samr.gov.cn/spcjs/yjjl/art/2026/art_8c5db9e136de447493f38874e9e21c87.html" } ], "legalNote": { "zh": "依据来源、产品身份和宣传场景分别审查。论文、预印本或专家说明不自动扩大食品功效宣称权限，转为销售材料后仍需核对广告边界；本版不是广告合规认证。", "en": "Review sources, product identity and communication context separately. Papers, preprints or expert explanations do not automatically expand food-claim permissions; sales reuse still needs advertising review. This edition is not regulatory certification." }, "deepStudy": { "zh": "拟议PICO：成年运动人群；单独牛磺酸对安慰剂；主要结局为规定距离计时。力竭时间、摄氧量与疲劳评分另列，不直接混合。预设运动类型、训练水平、剂量及时程差异；交叉试验使用配对效应及方差。亚组和个体预测须有足够数据，不能靠挑选阳性研究。", "en": "Proposed PICO: adults undertaking exercise; taurine alone versus placebo; fixed-distance time trial as the primary outcome. Time to exhaustion, oxygen uptake and fatigue are separate. Prespecify sport, training, dose and duration; use paired crossover effects/variances. Subgroup or individual prediction requires adequate data." }, "consumerFaq": [ { "question": { "zh": "有牛磺酸研究，就能说利葆瑞提高耐力吗？", "en": "Do taurine studies prove Libaorui improves endurance?" }, "answer": { "zh": "不能直接这样说。T1有跑步表现线索，但T2、T3骑行表现未改善；日量、配方与运动情境不同，尚无本成品匹配试验结果。", "en": "Not directly. T1 suggests a running benefit, while T2/T3 show no cycling-performance benefit. Dose, formulation and exercise differ, and a matching product trial was not verified." }, "sources": [ "T1", "T2", "T3" ] }, { "question": { "zh": "镁对所有运动者都一样有帮助吗？", "en": "Does magnesium help every exerciser equally?" }, "answer": { "zh": "现有研究不能支持一概而论。M1和M3未见所测耐力或表现收益；M2研究老年身体功能，人群和终点不同。需按营养状态与运动目标核对。", "en": "The selected studies do not support a blanket claim. M1/M3 show no benefit for their measured performance outcomes; M2 concerns older-adult physical function. Nutrient status and goals need appraisal." }, "sources": [ "M1", "M2", "M3" ] }, { "question": { "zh": "为什么还要做SR／Meta或产品试验？", "en": "Why commission SR/Meta or a product trial?" }, "answer": { "zh": "本快评是定向检索，不能排除遗漏或系统性偏差。SR／Meta可系统评价可比研究；要判断当前配方实际效果，还需要直接的成品证据。", "en": "Focused appraisal cannot exclude missing studies or selection bias. SR/Meta can assess comparable evidence systematically; the current formulation's effects still require direct product evidence." }, "sources": [ "T1", "T2", "T3", "M1", "M2", "M3", "G1" ] } ] }