Evidence OSMedical evidence & research
SOCIAL CONNECTION & SURGICAL OUTCOMES

Preoperative social connection and postoperative outcomes

Author-provided medRxiv manuscript v1. This case illustrates research scale and the boundaries of its findings.

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REAL RESEARCH · SYSTEMATIC REVIEW & META-ANALYSIS

Large-scale research. Reviewable work.

A systematic review and meta-analysis of preoperative social connection and postoperative outcomes. Explore the research scope, methods and limitations.

Explore the research caseAuthor-provided manuscript v1. Own research, not a paid customer engagement.
20,399Deduplicated records
445Included studies
72Studies in quantitative synthesis
Registration
CRD420261449181
Search date
2026-07-17
DOI
10.64898/2026.09.15.26363083
Quantitative synthesis
72 studies; principal analyses use 39 estimates from 33 studies.
View the manuscript source

Findings and uncertainty belong together

OutcomePooled association95% CIPrediction intervalCertainty
All-cause survivalHR 1.370.99–1.890.59–3.17Very low
Early postoperative mortalityOR 1.51.12–2.010.85–2.65Low
Non-home dischargeOR 1.951.35–2.810.71–5.34Low
Unplanned readmissionOR 1.140.98–1.330.84–1.56Low
Postoperative complicationsOR 1.10.96–1.25Not reported (k < 5)Very low

This research synthesises prognostic associations. It does not establish that improving social connection improves outcomes or predict individual risk. Confidence intervals for survival, readmission and complications include 1.

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METHOD REFERENCE

GRADE · Cochrane Handbook

Cochrane · Chapter 14

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GRADE evaluates a body of evidence for a particular outcome. Database inclusion or one study does not automatically establish high certainty.

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