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A complex case needs evidence checked for this patient.

Comorbidities, conflicting options or mismatched trial populations require source-level checks and professional review for one decision stage.

How does this scope address your concerns?

A public answer offers leads, but facts, contrary evidence and transfer conditions remain unchecked.

When this scope fits

One non-emergency complex-case question involving comorbidities, conflicting options or extrapolation
Ability to confirm authorization, records, treating responsibilities and relevant professional review

When the scope needs adjusting

General medical questions or public reading: use existing search tools and free Frontiers & News first
Emergency care, prescribing, on-call specialists or guaranteed best treatment
A publishable complete SR/Meta: commission research separately

REAL SOURCES · ILLUSTRATIVE REQUEST · DOWNLOADABLE SAMPLE

Complex-case evidence review: CKD and low-albuminuria extrapolation

Download sample packZIP

DAPA-CKD: primary composite event proportion

Unit: %

Dapagliflozin9.2 %

197 / 2,152

Placebo14.5 %

312 / 2,152

Real randomized trial; median follow-up 2.4 years, HR 0.61 (95% CI 0.51–0.72). Composite: sustained eGFR decline ≥50%, end-stage kidney disease, or kidney/cardiovascular death. Not an individual prediction for all CKD.

Check	Finding / sample content	Use
Direct population	Trial eGFR 25–75 and ACR 200–5000 mg/g	A lower-ACR case requires an explicit extrapolation check
Endpoint meaning	The chart is a composite, not kidney failure alone	Retain endpoint, denominator and time window
Unanswered items	This miniature example has not searched all low-ACR trials	A commission searches its agreed scope rather than asserting no evidence

SOURCES USED IN THIS EXAMPLE

DAPA-CKD randomized trial (NEJM, 2020; PMID 32970396)

Prepared 5 Oct 2026 · Selected references, not an exhaustive systematic search

Scope & acceptance

Work covered by the quote

One professional work package · review confirmed before contracting

One case-discussion stage; agree key questions, options, record pages, sources and timing.
Confirm relevant reviewers, responsibilities and availability before a project quote and milestones.
Deliver case facts/gaps, evidence applicability, source locations, review records and consultation questions.

Contract for start, draft, review and delivery milestones; approve new cases, questions and extra review first. Do not charge reusable completed work again.

No private-library setup, news-subscription or low-cost automated Q&A charge.
Treatment, prescribing, complete SR/Meta, outside consultations and treatment fees are excluded; unagreed third-party costs are separate.

Acceptance criteria

Each question has support or is explicitly unanswered. Facts, original locations, applicability and review status are checkable. Preserve supporting, contrary and uncertain evidence; a definite recommendation or better outcomes is not an acceptance condition.

Checking the evidence

Retain identifiable original sources, authorised inputs and missing information.

Workflow and inputs

From inputs to delivery

Explore the workflow and deliverable structure. This preview does not run searches, read real records or produce medical findings.

01 / WORKFLOW PREVIEW

Confirm the case and scope

Provide an overview and input volumes only. Confirm authorization, the choice, a safe waiting window and treating responsibilities. The current form does not collect real medical records.

Methods, sources and professional responsibilities

THE BASIS FOR THIS SCOPE

Why this approach? Inspect the basis.

Trace a clinical question to the research and distinguish effect size, certainty and the population.

PUBLIC DATABASE

PubMed

NLM / NIH

Check papers, abstracts and original sources

Find literature for a clinical question and inspect authors, publication dates, abstracts and full-text links.

Scope & access conditions

PubMed provides citations and abstracts, not journal full text. Access depends on the publisher or archive.

Read the official description

Open official source

PUBLIC DATABASE

Cochrane

Read systematic reviews and plain-language summaries

Explore a question’s research synthesis and the confidence researchers have in the findings.

Scope & access conditions

Plain-language summaries are public; full-review access varies. Applicability still depends on the population and question.

Open official source

METHOD REFERENCE

GRADE · Cochrane Handbook

Cochrane · Chapter 14

Show effect size and confidence separately

Present important outcomes, relative and absolute effects, available data and certainty, with reasons for downgrading.

Scope & access conditions

GRADE evaluates a body of evidence for a particular outcome. Database inclusion or one study does not automatically establish high certainty.

Open official source

These references support problem definition and evidence appraisal. Your conclusions still require project-specific sources and professional review.

The value of this commissionAgree the specialties, reviewers, key claims and format for one case discussion, and hand case facts, applicability, option matrices and source locations to the treating team.

Complex-case professional appraisalCompare alternatives and value

Prepare checked facts, options and evidence for an important clinical consultation, with agreed professional review.

What to assess	OpenEvidence	Evidence OS · Commissioned scope
Service focus	OpenEvidence's announcement describes clinical questions and case details, citations and DeepConsult cross-study synthesis. Its 2025 launch announcement offered DeepConsult free to verified U.S. clinicians.	Agree the specialties, reviewers, key claims and format for one case discussion, and hand case facts, applicability, option matrices and source locations to the treating team.
When to choose	Check current OpenEvidence access and results for self-directed queries and synthesis. Compare commissioned services when additional, scoped professional review and handover are required.	One defined decision. Agree record pages, options, claims, sources, review roles and revisions individually. Deliver a fact-and-gap register, evidence matrix, review records and consultation brief.

What the fee pays for: Proposed case-based quotation for the agreed professional appraisal. Confirm inputs and available reviewers first, then agree start, appraisal and handover payments. Retrieval, review and handover within the same scope are itemised in one quote.
Value beyond this task: Retained facts, source positions, applicability matrix, professional review records and unresolved questions. Completed reusable work is not billed twice.
How to assess value: Accept by dossier completeness, source location for key claims, completed review and clear unresolved issues.

Confirm availability, record-processing rights, reviewers and acceptance before paying. The commissioned scope does not establish superior accuracy, speed or clinical outcomes compared with OpenEvidence.

CHECK THE OFFICIAL SERVICE SCOPEOpenEvidence · Deep Consult — research reports and evidence synthesis

Reuse and updates after delivery

The commissioned work checks this case’s records, source locations and agreed professional review, with handover material for discussion. A public search answer is a lead, not a completed case review.

Agree reuse rights, retention and export periods, and future update fees when scoping.

Questions before commissioning

Why pay rather than use a medical search tool?

General search and public news do not require a paid EOS commission. This engagement performs case-specific input checks, applicability comparison and agreed professional review with handover materials. It does not promise superior answer performance.

Does the quote include specialist review?

Confirm the relevant specialty, reviewer, responsibilities and timing before specifying review in the quote. Unconfirmed personnel or outside consultations are not assumed included.

Do I need a subscription afterward?

No. Delivery ends the work package. New cases, questions or updates require another agreement, with no automatic renewal.

Define the delivery for your actual question.

Add your goal, available inputs and timing. Agree scope, review responsibilities and a quote before commissioning.

Request scope & quote

Explore other situations

Clinicians

Guidance has a conclusion, but a patient with comorbidities may not match its evidence.

Receive a patient–study–guidance crosswalk, applicability limits and agreed professional review records.

Quoted by case-review scopeSee the deliverable

Clinicians

Authorized case or research data need a defined preparation or analysis stage completed.

Receive the scoped data module, issues and missingness, results, figures, code and reproduction handover.

Analysis module from CNY 3,000See the deliverable

Clinicians

Explore sourced public developments in medicine and clinical AI.

Read free Frontiers & News, original sources and implications for patients and clinicians.

FreeSee the deliverable